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Antimalarial Drug Small Volume Parenteral Quinine Dihydrochloride Injection

Categories Small Volume Parenteral
Brand Name: Newlystar
Place of Origin: China
MOQ: 300, 000 amps
Payment Terms: L/C, T/T
Delivery Time: 45days
Packaging Details: 10 x 10amps/box
Model Number: 200mg/2ml; 400mg/4ml; 500mg/2ml; 600mg/2ml
Certification: GMP
Price: Negotiation
Supply Ability: one million amps per day
Product: Quinine Dihydrochloride Injection
Specification: 200mg/2ml; 400mg/4ml; 500mg/2ml; 600mg/2ml
Standard: BP, USP
Packing: 10 x 10amps/box
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Antimalarial Drug Small Volume Parenteral Quinine Dihydrochloride Injection

Antimalarial Drug Small Volume Parenteral Quinine Dihydrochloride Injection


Product : Quinine Dihydrochloride Injection

Specification : 200mg/2ml; 400mg/4ml; 500mg/2ml; 600mg/2ml

Standard : BP, USP

Packing : 10 x 10amps/box


Description :

An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.


Indication:

For the treatment of malaria and leg cramps


Pharmacodynamics

Quinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria. Quinine acts as a blood schizonticide although it also has gametocytocidal activity against P. vivax and P. malariae. Because it is a weak base, it is concentrated in the food vacuoles of P. falciparum. It is thought to act by inhibiting heme polymerase, thereby allowing accumulation of its cytotoxic substrate, heme. As a schizonticidal drug, it is less effective and more toxic than chloroquine. However, it has a special place in the management of severe falciparum malaria in areas with known resistance to chloroquine.


Mechanism of action

The theorized mechanism of action for quinine and related anti-malarial drugs is that these drugs are toxic to the malaria parasite. Specifically, the drugs interfere with the parasite's ability to break down and digest hemoglobin. Consequently, the parasite starves and/or builds up toxic levels of partially degraded hemoglobin in itself.

Product Tags:

Small Volume Injection

  
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